Description
BPC 157 is a pentaecapeptide that consists of 15 amino acids. The empirical formula of BPC 157 is C62H98N16O22, and molecular mass is 1419.53552. BPC 157 is also known as BPC-15 and Booly Protection Compound 15. The molecule has potent anti-inflammatory properties against chronic and acute inflammation.
Clinical studies have shown that BPC 157 plays a significant role in accelerating bone fracture healing in experimental animals. It promotes osteogenesis by enhancing the repair of segmental bone defects. Additionally, BPC 157 has been observed to expedite the healing of severed Achilles and quadriceps muscles in similar studies. This peptide is crucial for maintaining digestive tract function. It is abundant in the stomach, intestines and oesophagus. BPC 157 supports endothelial protection, stimulates angiogenesis and aids in wound repair.
BPC 157 has shown significant potential in alleviating symptoms of inflammatory bowel disease, other colon-related inflammatory conditions and ulcerative colitis. Research indicates that BPC 157 effectively suppresses symptoms of esophagitis and related disorders. It also helps reduce periodontitis, gingivitis and tissue extravasation in gingivomucosal areas. At the same time, lowering alveolar bone resorption by regulating calcium release from bone.
In cell cultures, samples treated with BPC 157 exhibited faster growth and outgrowth compared to those without the peptide. Interestingly, it does not interfere with cell proliferation and enhances cell survival under oxidative stress. FITC-phalloidin staining reveals that BPC 157 stimulates F-actin production. It is essential for fibroblast formation. Western blot analysis further shows that the peptide accelerates the phosphorylation of FAK paxillin and proteins.
Studies also suggest BPC 157 can aid in colitis healing and prevent stomach ulcers. Ongoing research is exploring its potential in treating liver damage caused by excessive alcohol consumption.